Trehalose restores functional autophagy suppressed by high glucose
نویسندگان
چکیده
منابع مشابه
Trehalose prevents neural tube defects by correcting maternal diabetes-suppressed autophagy and neurogenesis.
Preexisting maternal diabetes increases the risk of neural tube defects (NTDs). The mechanism underlying maternal diabetes-induced NTDs is not totally defined, and its prevention remains a challenge. Autophagy, an intracellular process to degrade dysfunction protein and damaged cellular organelles, regulates cell proliferation, differentiation, and apoptosis. Because autophagy impairment causes...
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ژورنال
عنوان ژورنال: Reproductive Toxicology
سال: 2019
ISSN: 0890-6238
DOI: 10.1016/j.reprotox.2019.02.005